MANAGEMENT: Joseph McMahon
DUKE INVENTOR: Ashutosh Chilkoti

Chromatography-free solutions for the purification of biological therapeutics.  Isolere Bio was co-founded with the vision of simplifying and streamlining the purification of biotherapeutics to improve global access to these important drugs.

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Monoclonal antibodies make up an effective and rapidly growing class of drugs. They are also critical research tools and essential for the development of many new diagnostics.

IsoTag Technology

The IsoTag technology works on the basis of affinity and phase separation. An engineered domain from Protein A captures the Fc portion of a monoclonal antibody (mAb). This affinity domain is fused to a stimulus responsive biopolymer. When in complex, the stimulus responsiveness is conferred to the mAb. This allows it to undergo phase separation from all other cellular contaminants. This process is fast, simple, and highly concentrating.