Category: Start-ups

THE PROBLEM:

THE SOLUTION:

Skin elasticity is both important for planning, guiding, and evaluating procedures and treatments in aesthetic dermatology and crucial for tracking and managing life-threatening chronic conditions like Graft-Versus-Host-Disease, yet existing methods are subjective, qualitative, or unreliable, causing the NIH to declare that “there is an urgent need for the development of more quantifiable and reproducible measurements”.

MicroElastic aims for early assessment, active feedback speeds, tailored treatments while reducing discomfort and other complications, reducing costs, and improving outcomes.

MicroElastic is taking its functional prototype into clinical testing and developing its first commercial product via funding from an NIH STTR grant and is negotiating a strategic partnership in the aesthetic space for application to anti-aging procedures. MicroElastic will be seeking funding in 2018 to complete development and regulatory approval as a class II device under the 510(k) pathway.

The Company’s goal is to use targeted, low-dose gene therapies to address this glycogen storage disorder. AskBio’s double strand adeno-associated virus vectors (AAV) have the potential to provide treatment at a lower effective dose and with more cell type specificity and less potential systemic effects than other AVV.

Pompe Disease

Pompe Disease is an inherited rare disorder (< 1:40,000 births) caused by the deficiency of acid-alpha-glucosidase (GAA) in muscle. This deficiency results in the accumulation of glycogen in organs and tissues, especially muscles, which can impair their ability to function normally. While enzyme replacement has shown promise in patients with infantile-onset Pompe disease, no curative therapy is available. More information on Pompe disease is available at: https://ghr.nlm.nih.gov/condition/pompe-disease.

The Problem :

The Solution:

Managing serious illness is unique for each patient. Prepped Health offers multiple tools that empower patients to take control of their healthcare journey.

They have created platforms that center around the three pillars of patient engagement:

• Communication
• Education
• Navigation

Prepped Health has established use cases for their system in:

• Palliative care
• Hospice care
• COPD care
• Cancer Care

Prepped Health ensures that patients will be ready for their journey with serious illness, leading to better health outcomes and a higher quality of life for patients and their loved ones.

Mobile Application

Prepped is a mobile application that generates helpful, timely suggested questions for patients and caregivers to ask their clinical providers. The app uses a strength in numbers in approach – Prepped crowdsources questions submitted by national experts, patients, caregivers and other users to recommend the best questions for the patient based on the patient’s profile and where they are in the disease process. Current versions of Prepped are focused on patients with cancer and/or COPD

Infinia ML uses advanced machine learning techniques to solve business challenges for Fortune 500 companies. Our algorithms unlock the hidden potential of our clients’ data, helping them automate complex processes, enhance employee efficiency, and pioneer transformational breakthroughs. Led by serial AI entrepreneur Robbie Allen and computer science luminary Lawrence Carin, our team’s combined accomplishments include over 500 published papers, 30 granted patents, 11 authored or co-authored books, and five PhDs.

“The company is, in many ways, the translation of the work we’ve been doing at Duke for many years on machine learning,” Carin said in an interview with the Triangle Business Journal.

The inventors’ story began at the time of the handheld computer and a growing popularity amongst clinicians for pocket-sized calculators and for ready information resources such as drugs and vaccine schedules. They saw a gap in the delivery of timely updates for management of infections in their large academic hospital in North Carolina. The solution was CustomID® which they first launched for PDA and later as a web app for display either via desktop or mobile internet browser. Subsequently, in 2005, the Dutch Working Party on Antibiotic Policy (SWAB) licensed the CustomID® framework and installed their guide in 30 hospitals in the Netherlands. CCDS is now taking CustomID® for offering beyond the Duke enterprise.

CustomID®

CustomID® is different from other antimicrobial guides by providing site-specific content, easily customizable, which is key for timely updates about drug shortages, outbreaks, and site-specific policies and protocols.

The company vision is to forward cutting-edge technology and knowledge transfer that is suitable for all medical disciplines, a vision to keep at the forefront, the goal of saving lives.

Monoclonal antibodies make up an effective and rapidly growing class of drugs. They are also critical research tools and essential for the development of many new diagnostics.

IsoTag Technology

The IsoTag technology works on the basis of affinity and phase separation. An engineered domain from Protein A captures the Fc portion of a monoclonal antibody (mAb). This affinity domain is fused to a stimulus responsive biopolymer. When in complex, the stimulus responsiveness is conferred to the mAb. This allows it to undergo phase separation from all other cellular contaminants. This process is fast, simple, and highly concentrating.

Scanslated software analyzes the text of a standard radiology report, translates that text into simple language, and displays the report results on a diagrammatic, interactive webpage.

THE PROBLEM

92% of Americans have access to their medical records online. More than 50% of patients who use the online portal are accessing their radiology reports. However, these reports are technical documents written in medical terminology, and most patients don’t understand them.

THE SOLUTION

We’re creating a radiology report that people can actually understand. Our software analyzes the text of a standard radiology report, translates that text into simple language, and displays the report results on a diagrammatic, interactive webpage.